Usage of Stem Cell Therapy

Blood or hematopoietic stem cells are the most widely used stem cells, which are used for frequently used for stem cell transplants such as bone marrow transplantation. This type of Stem Cell Therapy is used for treating some immune system and blood disorders and diseases, as well as for rebuilding blood systems following treatment of some types of cancer. Disease such as Parkinson’s disease is also treated with this kind of Stem Cell Therapy. Groundwork studies have shown that bone marrow cells can provide beneficial effects when injected into an affected heart. In few of the cases, stem cells may be infused straight in the blood, and the cells make their way to the right, location and start creating new tissues and cells required. Other cases require cells to be injected into a tissue or an organ, where cells are needed.

The main aim of a Stem Cell Therapy is transplanting stem cells in the patient and then directing them to the right place where it can divide and differentiate to form new and functioning tissues or can repair the tissues that have been damaged due to any disease or disorder. However, the risk of the stem cells not working in the desired manner is there, but researchers are continuously working to find new ways of making Stem Cell Therapy as safe as possible for different patients.

For successful usage of stem cells to treat different diseases, researchers first have to come up with source of ample amount of stem cells, as many adult cells does not have the ability to divide and multiply in huge numbers. The next challenge that scientists face in the use of Stem Cell Therapy is creating of the required type of cell in lab conditions, or after transplanting the cell into the patient.

The risk of rejection of the new stem cells by the immune system of the receiving patient also exists while using stem cells for treating diseases. This is another big concern and roadblock in the way of successful usage of Stem Cell Therapy. New ways of protecting stem cells from attack of the immune systems are being explored by researchers these days.

Research institutes and health centers like Giostar, not only offers Stem Cell Therapy for various diseases, but are also involved in consistent research to make sure that the therapy is safe and that the stem cells remain functional throughout the lifespan of the patient. 

Potential of Stem Cells in Diabetes Treatment

The incredible potential of stem cells and possibility of using them for curing fatal diseases has been in the news of late. However, special attention has been paid in the field of administering Stem Cell Therapy for Diabetes Treatment. The reason, we all know, is the higher number of individuals being affected by this disease and the complications that it can create, if not treated in the right time and manner. Complications such as risk of stroke, cardiovascular diseases, lower limb amputation, kidney failure, glaucoma, dementia, and many more are included in the list of diabetes associated risks.

Although both the types of diabetes has their corresponding treatment procedures, but none of them is completely effective in curing the disease. Oral medications, insulin injections, etc just try to control the complications associated with diabetes. The good news is that the field of Regenerative medicine has shown prospects of changing the scenario all together for diabetic patients. Research has shown that Stem Cell Therapy can help in regeneration of affected cells and can boost insulin producing ability of the pancreas. In recent trials adipose stem cells have been administered in patients has proved to be effective treatment option for type-2 diabetes. It has led to enhanced efficiency in exercise, supplementation, and even dietary changes.

Clinical trials are being carried out continuously to develop and authenticate Stem Cell Therapy for Diabetes Treatment in humans. Researchers are now focusing on using embryonic cells and then inducing to change to beta cells, which can be then transplanted in the patient. Like any innovation there are several roadblocks in the path of Stem Cell Therapy to develop into a complete safe treatment option for degenerative diseases. The path from laboratory to clinics and health centers is pretty tough, but endeavor of scientists and support from world class research organizations is making things happen for Stem Cell Therapy.

Scientists are now working on biliary cells, which are instructed to become islets. The target of recent studies is to establish these cells, so that they can be used in reversing diabetes in patients. Researchers are working hard to try out every possibility of transplanting stem cells and protecting them from being destroyed by the immune system.

Global research centers such as Giostar is now offering unique Diabetes Treatment options with stem cells, and has paved the way for better lifestyle for patients, and is trying to wipe away insulin injections from the scene altogether. 

Stem Cells Treatment for Arthritis

Stem cells and its treatment modalities can definitely be the next possible treatment “on the go”! It has been noted by huge accumulated data that stem cells can definitely do wonders for treating many degenerative conditions such as arthritis.

Researchers worldwide are working hard to find out new innovative ways to infuse stem cells in the joints exhibiting the problem of arthritis. It has as well been tried to figure out, which type of stem cells can express more healing power in case of joint disorders such as arthritis.

Arthritis is known to be an auto immune joint disorder, wherein the cushioning material known to be a cartilage is destroyed by body’s own immune cells; due to which the fiction between two bones of the joints is increased considerably, leading to its pain. Accordingly, many different conditions associated with joint degeneration and arthritic pain has been evaluated.

Out of many different forms of arthritis, the most degenerative form, so far has been reported to be osteoarthritis. Whereas the most severe form of arthritic disorders is noted down as rheumatoid arthritis. It has been statistically analyzed that the most common group affected with the arthritic issues are age group in the range of 40-60. Some of the early bird symptoms, categorically noted for arthritis are chronic pain in the joints, muscles as well as bones. Reported evidences of morning stiffness and occasional swelling that can be reduced without medical applications.

Conventional treatments that are offered to arthritis are generally steroidal medicines that can minimize systemic inflammatory attacks, some physiotherapies and weight loss to reduce pressure on joints. Although, current treatments report no long term effectiveness; on the contrary over exposure of steroidal medicines has proven to be harmful.

With the scientific advancements, the clinical applications of stem cells have been widely reported with significant effectiveness, but without any adverse reaction. The upgraded technology has enabled scientists and medical professionals to isolated stem cells from many autologous as well as allogenic sources such as bone marrow, adipose tissues, etc. These stem cells are enriched and concentrated outside the body in a controlled environment to add on its effectiveness. Once ready, these stem cells are then re-infused back into the body directly into the joints. Technically, these stem cells are as well stimulated with patient’s own platelet rich plasma to stimulate them inside the body to promote production of many growth hormones; which can initiate the process of regeneration and repair of cartilaginous cells known to be chondrocytes.

The regeneration and repair of chondrocytes can possibly help to minimize the progression of its damage and reduce the pain associated with arthritis.

Thus, stem cells treatment for arthritis, has moved ahead to reach to many new avenues and successes through global clinical trials. Researchers are investigating many new ways to inject stem cells in the body to maximize its effectiveness with minimum manipulation. Although, the ultimate goal of many on-going studies is to evaluate safety and feasibility of stem cells and their applications in case of diseased conditions.

To know more about  Arthritis Treatment and  Stem Cell therapy  visit our website : giostar.com

Stem Cell Treatment A New Hope for Patients

Stem cells are the “natural resources” available throughout the life of an individual and are responsible to make over with body’s natural wear and tear, such as wound healing, organ repair in case of crisis, immune build up of an individual, etc.

Stem cells treatment for possible debilitating diseases has exceptionally become a new defined era in the field of medical science; through which we can save many struggling lives that are currently facing health stigma! Stem cells being our own cells can have access to entire body without any medical hurdles such as rejection, other opportunistic infections etc.

In order to understand, what difference these little wonders can bring in for a diseased individual; we need to first understand their underlying mechanism.

What are these stem cells?

Stem cells are the unique, inherent cells of the body; which show their first appearance after the union of the male and female gametes. These are the first cells that are formed in the eight celled stage, after fertilization and through repeated cellular divisions. These stem cells have the power to give rise to an entire human being through proper signalling pathways.

It has also been identified that at each stage, stem cell lose its potency to become cell of any lineage; according embryonic stem cells are the cells of highest potency i.e. they are capable to be any type of cells, on the contrary, adult stem cells are multipotent that can only be selectively differentiated.  

What is stem cells treatment?

Stem cells treatment is evident based scientific miracle, wherein the potential of stem cells, to give rise to any type of cell; can be exploited in a specific manner to treat variety of diseases linked with the cell degeneration such as live problems, neurodegenerative disorders, etc.

With the help of upgraded technology, it is possible to isolate stem cells from the abundant sources such as bone marrow, adipose tissue, etc. Once isolated, these stem cells can be enriched in the clean and controlled environment to increase number of stem cells; which can be confirmed with the help of characterization techniques. These enriched stem cells can thus be re-infused back in the body through unique route of administration.

Once inside the body, these stem cells can detect site of injury through their strong networking capacity. Once they find their home, these stem cells can stimulate various growth factors and immune cells to regenerate dead and damaged cells.

What type of diseases can be cured?

Stem cell treatment can be used to treat variety of degenerative diseases such as:

·         Neurodegenerative diseases

·         Metabolic disorders such as liver problems, diabetes, etc.

·         Cosmetic treatments such as anti-ageing treatments

·         Arthritis related issues

The potential of stem cells has been proven through large data accumulated by worldwide clinical trials and studies. So far, no adverse reaction has been reportedly noted in large clinical studies and findings. However, the effectiveness of stem cells treatment is observed to be different on different individuals.

Although, every new finding has to pass through stringent studies providing effective solutions and hence is always advisable to analyse the same through positive and negative effects.

To know more about Liver Cirrhosis Treatment and  Stem Cell therapy  visit our website : giostar.com

Engineering Stem Cells To Enhance Antibody Therapy

Vaccines and antibodies have long been employed as weapons in the battle against disease. They work by boosting our immune systems to target pathologies, such as Crohn’s Disease or certain cancers. But, in some cases, the protection conferred by antibodies “wears off” too quickly.

Now, a team of Canadian researchers has demonstrated for the first time that stem cells can be used to deliver antibodies more effectively than administration of the antibodies themselves—and over longer periods of time.

Having recently shown that stem cells could be used to reverse osteoporosis, University of Toronto professor John E. Davies partnered with researchers Lorena Braid, Wei-Gang Hu and Les Nagata of Defence Research and Development Canada (DRDC) to see if they could extend the effectiveness of monoclonal antibodies (mAbs), a type of treatment that stimulates the immune system to fight unwanted cells or proteins.

“Many patients who are receiving mAb treatment for Crohn’s or rheumatoid arthritis have to visit the clinic frequently for new doses due to their limited window of effectiveness,” said Davies, who is appointed at U of T’s Faculty of Dentistry and the Institute of Biomaterials & Biomedical Engineering (IBBME). “Our study provides a proof-of-concept that stem cells can be engineered to deliver this type of antibody over an extended period of time.”

The team engineered their stem cells, sourced from human umbilical cord tissue, to produce mAbs that neutralize the Venezuelan equine encephalitis virus (VEEV), a mosquito-borne pathogen. They then compared the effectiveness of treatment using the stem cell-delivered mAbs to the direct administration of purified mAbs themselves.

“The results were eye-opening,” reported Hu, the corresponding author for this research. “While traditional [purified] antibody administration provided protection for two or three days after injection, the engineered stem cells with the transgene encoding anti-VEEV protected the majority of the mice for 10 days, with protective antibody levels up to 38 days.”

Their results were published on August 15, 2016 as a featured paper in the journal Stem Cells Translational Medicine.

“This study has broad implications for a range of mAb therapies,” said Davies. “Extended delivery can have a tremendous impact on many indications including immune and inflammatory diseases, and in particular the field of immuno-oncology.”

Stem cells sourced from umbilical cord tissue, known as Human Umbilical Cord Perivascular Cells (HUCPVCs), were first isolated by Davies at U of T. This development led to the founding of Toronto-based company Tissue Regeneration Therapeutics Inc. in 2004, which supplied the cells for this study.

Source : http://goo.gl/VbrGl7

Stem Cell Therapy for Osteoarthritis in India

Osteoarthritis is  the most common form of artheritis, usual form of chronic disorder  related to the joints that is found in millions of people all across the globe. It is also know as degenerative  joint disease or degenerative artheritis that takes place due to the brek down joint cartilage and the underlying bone. OA can affect any joint, but it occurs most often in knees, hips, lower back and neck, small joints of the fingers and the bases of the thumb and big toe.

Due to the breakdown of the cartilage, pain , selling up and discomfort in the movemnt of the joint is noticed and it can be seen in all age group and genders, however older people are highly prone to osteoartheritis. Considerable growth in osteoartheritis treatment in India is evident now a days. Initially Osteoartheritis was considered just a wear and tear in joint, which now getting more significant approach to treat the disease. Osteoarthritis is the main cause of joint pain both in animals and humans.  Natural cartilage regeneration is very limited and no current drug therapies are curative, but rather look to reduce the symptoms associated with the degeneration. More recently, the use of embryonic stem cell therapy for the treatment of artheritis, especially osteoartheritis.

The symptoms of osteoartheritis vary quite diversely, however few of the common traits of the disease include

Limited range of motion or stiffness 

Clicking or cracking sound when a joint bends

Mild swelling around a joint

Many people believe that the effects of osteoarthritis are inevitable, so they don’t do anything to manage it, however osteoartheritis treatment in India through stem cell therapy is gaining awareness and successful upward trend in the curing the disease.

Joint aspiration, MRI and X ray are the modes through which one can test if he/she is suffering from or a victim of Osteoartheritics.Traditonally , getting involved in physical activity, streching and weight management was considered to tackle the disease, but development in the stem cell therapy and successful result of effective and efficient implementation of the treatment has proven the potential of the mode of treatment.

Stem Cell Treatment In India

Stem cells are capable of dividing and renewing themselves for long periods. Unlike muscle cells, blood cells, or nerve cells—which do not normally replicate themselves—stem cells may replicate many times, or proliferate. Regardless of their source—have three general properties: they are capable of dividing and renewing themselves for long periods; they are unspecialized; and they can give rise to specialized cell types. Stem cells have been successfully isolated from variety of human tissues including orofacial tissues. Initial evidence from pioneering studies has documented the likely breakthrough that stem cells offer for various life-threatening diseases that have so far defeated modern medical care.

Scientists are still under the process of understanding the several unanswered questions related to stem cells as stem cell treatment is the most promising therapy for many devastating degenerative diseases. Anemia, leukemia, lymphoma are some of the blood related disorders treated through stem cell treatment in India.

Now the question that strikes into the mind of every reader is what are stem cells. The answer is - They are unspecialized cells with an extraordinary ability to self-renew, capable of differentiating into one or more specialized cell types playing a crucial role in homeostasis and tissue repair. Based on their origin, stem cells are categorized either as embryonic stem cells (ESCs) or as postnatal stem cells/somatic stem cells/adult stem cells (ASCs). Embryonic stem cells (ESCs) are derived from embryos that are 2–11 days old called blastocysts. They are best grown from supernumerary embryos obtained from in vitro fertilization centers. Adult stem cells are found in most adult tissues. The plasticity of an adult stem cell is described as its ability to expand beyond its potential irrespective of the parent cell from which it is derived. For example, dental pulp stem cells not only develop into tooth tissue but also have the ability to differentiate into neuronal tissue.

Depending on their origin, adult stem cells can be further classified as hemopoetic stem cells (HSCs) and mesenchymal stem cells (MSCs). Stem cell treatment for many diseases are now the most reliable and effective method to cure it.