Usage of Stem Cell Therapy

Blood or hematopoietic stem cells are the most widely used stem cells, which are used for frequently used for stem cell transplants such as bone marrow transplantation. This type of Stem Cell Therapy is used for treating some immune system and blood disorders and diseases, as well as for rebuilding blood systems following treatment of some types of cancer. Disease such as Parkinson’s disease is also treated with this kind of Stem Cell Therapy. Groundwork studies have shown that bone marrow cells can provide beneficial effects when injected into an affected heart. In few of the cases, stem cells may be infused straight in the blood, and the cells make their way to the right, location and start creating new tissues and cells required. Other cases require cells to be injected into a tissue or an organ, where cells are needed.

The main aim of a Stem Cell Therapy is transplanting stem cells in the patient and then directing them to the right place where it can divide and differentiate to form new and functioning tissues or can repair the tissues that have been damaged due to any disease or disorder. However, the risk of the stem cells not working in the desired manner is there, but researchers are continuously working to find new ways of making Stem Cell Therapy as safe as possible for different patients.

For successful usage of stem cells to treat different diseases, researchers first have to come up with source of ample amount of stem cells, as many adult cells does not have the ability to divide and multiply in huge numbers. The next challenge that scientists face in the use of Stem Cell Therapy is creating of the required type of cell in lab conditions, or after transplanting the cell into the patient.

The risk of rejection of the new stem cells by the immune system of the receiving patient also exists while using stem cells for treating diseases. This is another big concern and roadblock in the way of successful usage of Stem Cell Therapy. New ways of protecting stem cells from attack of the immune systems are being explored by researchers these days.

Research institutes and health centers like Giostar, not only offers Stem Cell Therapy for various diseases, but are also involved in consistent research to make sure that the therapy is safe and that the stem cells remain functional throughout the lifespan of the patient. 

Potential of Stem Cells in Diabetes Treatment

The incredible potential of stem cells and possibility of using them for curing fatal diseases has been in the news of late. However, special attention has been paid in the field of administering Stem Cell Therapy for Diabetes Treatment. The reason, we all know, is the higher number of individuals being affected by this disease and the complications that it can create, if not treated in the right time and manner. Complications such as risk of stroke, cardiovascular diseases, lower limb amputation, kidney failure, glaucoma, dementia, and many more are included in the list of diabetes associated risks.

Although both the types of diabetes has their corresponding treatment procedures, but none of them is completely effective in curing the disease. Oral medications, insulin injections, etc just try to control the complications associated with diabetes. The good news is that the field of Regenerative medicine has shown prospects of changing the scenario all together for diabetic patients. Research has shown that Stem Cell Therapy can help in regeneration of affected cells and can boost insulin producing ability of the pancreas. In recent trials adipose stem cells have been administered in patients has proved to be effective treatment option for type-2 diabetes. It has led to enhanced efficiency in exercise, supplementation, and even dietary changes.

Clinical trials are being carried out continuously to develop and authenticate Stem Cell Therapy for Diabetes Treatment in humans. Researchers are now focusing on using embryonic cells and then inducing to change to beta cells, which can be then transplanted in the patient. Like any innovation there are several roadblocks in the path of Stem Cell Therapy to develop into a complete safe treatment option for degenerative diseases. The path from laboratory to clinics and health centers is pretty tough, but endeavor of scientists and support from world class research organizations is making things happen for Stem Cell Therapy.

Scientists are now working on biliary cells, which are instructed to become islets. The target of recent studies is to establish these cells, so that they can be used in reversing diabetes in patients. Researchers are working hard to try out every possibility of transplanting stem cells and protecting them from being destroyed by the immune system.

Global research centers such as Giostar is now offering unique Diabetes Treatment options with stem cells, and has paved the way for better lifestyle for patients, and is trying to wipe away insulin injections from the scene altogether. 

Stem Cells Treatment for Arthritis

Stem cells and its treatment modalities can definitely be the next possible treatment “on the go”! It has been noted by huge accumulated data that stem cells can definitely do wonders for treating many degenerative conditions such as arthritis.

Researchers worldwide are working hard to find out new innovative ways to infuse stem cells in the joints exhibiting the problem of arthritis. It has as well been tried to figure out, which type of stem cells can express more healing power in case of joint disorders such as arthritis.

Arthritis is known to be an auto immune joint disorder, wherein the cushioning material known to be a cartilage is destroyed by body’s own immune cells; due to which the fiction between two bones of the joints is increased considerably, leading to its pain. Accordingly, many different conditions associated with joint degeneration and arthritic pain has been evaluated.

Out of many different forms of arthritis, the most degenerative form, so far has been reported to be osteoarthritis. Whereas the most severe form of arthritic disorders is noted down as rheumatoid arthritis. It has been statistically analyzed that the most common group affected with the arthritic issues are age group in the range of 40-60. Some of the early bird symptoms, categorically noted for arthritis are chronic pain in the joints, muscles as well as bones. Reported evidences of morning stiffness and occasional swelling that can be reduced without medical applications.

Conventional treatments that are offered to arthritis are generally steroidal medicines that can minimize systemic inflammatory attacks, some physiotherapies and weight loss to reduce pressure on joints. Although, current treatments report no long term effectiveness; on the contrary over exposure of steroidal medicines has proven to be harmful.

With the scientific advancements, the clinical applications of stem cells have been widely reported with significant effectiveness, but without any adverse reaction. The upgraded technology has enabled scientists and medical professionals to isolated stem cells from many autologous as well as allogenic sources such as bone marrow, adipose tissues, etc. These stem cells are enriched and concentrated outside the body in a controlled environment to add on its effectiveness. Once ready, these stem cells are then re-infused back into the body directly into the joints. Technically, these stem cells are as well stimulated with patient’s own platelet rich plasma to stimulate them inside the body to promote production of many growth hormones; which can initiate the process of regeneration and repair of cartilaginous cells known to be chondrocytes.

The regeneration and repair of chondrocytes can possibly help to minimize the progression of its damage and reduce the pain associated with arthritis.

Thus, stem cells treatment for arthritis, has moved ahead to reach to many new avenues and successes through global clinical trials. Researchers are investigating many new ways to inject stem cells in the body to maximize its effectiveness with minimum manipulation. Although, the ultimate goal of many on-going studies is to evaluate safety and feasibility of stem cells and their applications in case of diseased conditions.

To know more about  Arthritis Treatment and  Stem Cell therapy  visit our website : giostar.com

Stem Cell Treatment A New Hope for Patients

Stem cells are the “natural resources” available throughout the life of an individual and are responsible to make over with body’s natural wear and tear, such as wound healing, organ repair in case of crisis, immune build up of an individual, etc.

Stem cells treatment for possible debilitating diseases has exceptionally become a new defined era in the field of medical science; through which we can save many struggling lives that are currently facing health stigma! Stem cells being our own cells can have access to entire body without any medical hurdles such as rejection, other opportunistic infections etc.

In order to understand, what difference these little wonders can bring in for a diseased individual; we need to first understand their underlying mechanism.

What are these stem cells?

Stem cells are the unique, inherent cells of the body; which show their first appearance after the union of the male and female gametes. These are the first cells that are formed in the eight celled stage, after fertilization and through repeated cellular divisions. These stem cells have the power to give rise to an entire human being through proper signalling pathways.

It has also been identified that at each stage, stem cell lose its potency to become cell of any lineage; according embryonic stem cells are the cells of highest potency i.e. they are capable to be any type of cells, on the contrary, adult stem cells are multipotent that can only be selectively differentiated.  

What is stem cells treatment?

Stem cells treatment is evident based scientific miracle, wherein the potential of stem cells, to give rise to any type of cell; can be exploited in a specific manner to treat variety of diseases linked with the cell degeneration such as live problems, neurodegenerative disorders, etc.

With the help of upgraded technology, it is possible to isolate stem cells from the abundant sources such as bone marrow, adipose tissue, etc. Once isolated, these stem cells can be enriched in the clean and controlled environment to increase number of stem cells; which can be confirmed with the help of characterization techniques. These enriched stem cells can thus be re-infused back in the body through unique route of administration.

Once inside the body, these stem cells can detect site of injury through their strong networking capacity. Once they find their home, these stem cells can stimulate various growth factors and immune cells to regenerate dead and damaged cells.

What type of diseases can be cured?

Stem cell treatment can be used to treat variety of degenerative diseases such as:

·         Neurodegenerative diseases

·         Metabolic disorders such as liver problems, diabetes, etc.

·         Cosmetic treatments such as anti-ageing treatments

·         Arthritis related issues

The potential of stem cells has been proven through large data accumulated by worldwide clinical trials and studies. So far, no adverse reaction has been reportedly noted in large clinical studies and findings. However, the effectiveness of stem cells treatment is observed to be different on different individuals.

Although, every new finding has to pass through stringent studies providing effective solutions and hence is always advisable to analyse the same through positive and negative effects.

To know more about Liver Cirrhosis Treatment and  Stem Cell therapy  visit our website : giostar.com

Engineering Stem Cells To Enhance Antibody Therapy

Vaccines and antibodies have long been employed as weapons in the battle against disease. They work by boosting our immune systems to target pathologies, such as Crohn’s Disease or certain cancers. But, in some cases, the protection conferred by antibodies “wears off” too quickly.

Now, a team of Canadian researchers has demonstrated for the first time that stem cells can be used to deliver antibodies more effectively than administration of the antibodies themselves—and over longer periods of time.

Having recently shown that stem cells could be used to reverse osteoporosis, University of Toronto professor John E. Davies partnered with researchers Lorena Braid, Wei-Gang Hu and Les Nagata of Defence Research and Development Canada (DRDC) to see if they could extend the effectiveness of monoclonal antibodies (mAbs), a type of treatment that stimulates the immune system to fight unwanted cells or proteins.

“Many patients who are receiving mAb treatment for Crohn’s or rheumatoid arthritis have to visit the clinic frequently for new doses due to their limited window of effectiveness,” said Davies, who is appointed at U of T’s Faculty of Dentistry and the Institute of Biomaterials & Biomedical Engineering (IBBME). “Our study provides a proof-of-concept that stem cells can be engineered to deliver this type of antibody over an extended period of time.”

The team engineered their stem cells, sourced from human umbilical cord tissue, to produce mAbs that neutralize the Venezuelan equine encephalitis virus (VEEV), a mosquito-borne pathogen. They then compared the effectiveness of treatment using the stem cell-delivered mAbs to the direct administration of purified mAbs themselves.

“The results were eye-opening,” reported Hu, the corresponding author for this research. “While traditional [purified] antibody administration provided protection for two or three days after injection, the engineered stem cells with the transgene encoding anti-VEEV protected the majority of the mice for 10 days, with protective antibody levels up to 38 days.”

Their results were published on August 15, 2016 as a featured paper in the journal Stem Cells Translational Medicine.

“This study has broad implications for a range of mAb therapies,” said Davies. “Extended delivery can have a tremendous impact on many indications including immune and inflammatory diseases, and in particular the field of immuno-oncology.”

Stem cells sourced from umbilical cord tissue, known as Human Umbilical Cord Perivascular Cells (HUCPVCs), were first isolated by Davies at U of T. This development led to the founding of Toronto-based company Tissue Regeneration Therapeutics Inc. in 2004, which supplied the cells for this study.

Source : http://goo.gl/VbrGl7

Stem Cell Therapy for Osteoarthritis in India

Osteoarthritis is  the most common form of artheritis, usual form of chronic disorder  related to the joints that is found in millions of people all across the globe. It is also know as degenerative  joint disease or degenerative artheritis that takes place due to the brek down joint cartilage and the underlying bone. OA can affect any joint, but it occurs most often in knees, hips, lower back and neck, small joints of the fingers and the bases of the thumb and big toe.

Due to the breakdown of the cartilage, pain , selling up and discomfort in the movemnt of the joint is noticed and it can be seen in all age group and genders, however older people are highly prone to osteoartheritis. Considerable growth in osteoartheritis treatment in India is evident now a days. Initially Osteoartheritis was considered just a wear and tear in joint, which now getting more significant approach to treat the disease. Osteoarthritis is the main cause of joint pain both in animals and humans.  Natural cartilage regeneration is very limited and no current drug therapies are curative, but rather look to reduce the symptoms associated with the degeneration. More recently, the use of embryonic stem cell therapy for the treatment of artheritis, especially osteoartheritis.

The symptoms of osteoartheritis vary quite diversely, however few of the common traits of the disease include

Limited range of motion or stiffness 

Clicking or cracking sound when a joint bends

Mild swelling around a joint

Many people believe that the effects of osteoarthritis are inevitable, so they don’t do anything to manage it, however osteoartheritis treatment in India through stem cell therapy is gaining awareness and successful upward trend in the curing the disease.

Joint aspiration, MRI and X ray are the modes through which one can test if he/she is suffering from or a victim of Osteoartheritics.Traditonally , getting involved in physical activity, streching and weight management was considered to tackle the disease, but development in the stem cell therapy and successful result of effective and efficient implementation of the treatment has proven the potential of the mode of treatment.

Stem Cell Treatment In India

Stem cells are capable of dividing and renewing themselves for long periods. Unlike muscle cells, blood cells, or nerve cells—which do not normally replicate themselves—stem cells may replicate many times, or proliferate. Regardless of their source—have three general properties: they are capable of dividing and renewing themselves for long periods; they are unspecialized; and they can give rise to specialized cell types. Stem cells have been successfully isolated from variety of human tissues including orofacial tissues. Initial evidence from pioneering studies has documented the likely breakthrough that stem cells offer for various life-threatening diseases that have so far defeated modern medical care.

Scientists are still under the process of understanding the several unanswered questions related to stem cells as stem cell treatment is the most promising therapy for many devastating degenerative diseases. Anemia, leukemia, lymphoma are some of the blood related disorders treated through stem cell treatment in India.

Now the question that strikes into the mind of every reader is what are stem cells. The answer is - They are unspecialized cells with an extraordinary ability to self-renew, capable of differentiating into one or more specialized cell types playing a crucial role in homeostasis and tissue repair. Based on their origin, stem cells are categorized either as embryonic stem cells (ESCs) or as postnatal stem cells/somatic stem cells/adult stem cells (ASCs). Embryonic stem cells (ESCs) are derived from embryos that are 2–11 days old called blastocysts. They are best grown from supernumerary embryos obtained from in vitro fertilization centers. Adult stem cells are found in most adult tissues. The plasticity of an adult stem cell is described as its ability to expand beyond its potential irrespective of the parent cell from which it is derived. For example, dental pulp stem cells not only develop into tooth tissue but also have the ability to differentiate into neuronal tissue.

Depending on their origin, adult stem cells can be further classified as hemopoetic stem cells (HSCs) and mesenchymal stem cells (MSCs). Stem cell treatment for many diseases are now the most reliable and effective method to cure it.

Stem Cell Treatment in India

Since last decade, there has been an epidemiological transition occurring in global developed and developing countries. Some forms of diseases such as cardiovascular disorders, diabetes, metabolic disorders are widely distributed diseases, with rapid progression. While research on stem cells and their application is accelerating at a jet speed, the field is still in its developmental phase.

Until recently, considering the common facilities that were offered to developed countries; research and development of stem cells was mainly concentrated in affluent parts of the world such as USA, Germany, Japan, etc. However, with the due regards to their potential; even developing countries such as India, is now actively participating in the field of stem cells treatments; with the latest innovation of new technology and more knowledge.

In general as well, the demands of technological advancements, skilled medical professional and compliant facilities is more in developing countries because it has been estimated as per WHO report that more than 85% of the chronic diseases death are more prevalent in developing countries; besides the rate is going to double up in coming years. Thus, scientists are more focusing on the research; based on facts and figures of the developing countries to innovate technical advancements on the local context making it to be readily available within affordable range to local people.

It has been strongly supported that India is one of the few developing countries that have strongly begun to work on novel stem cells technology and development. India has manpower, technical strength, aptitude and potential ability to develop supportive stem cells applications to meet its health demands, budget and potential to make important global contributions to this emerging field. It has as well been noticed that almost more than 150 publications have been published in peer reviewed journals at the beginning of the current decade.

Besides, having skills and infrastructure, the acceptability towards the cutting edge technology like stem cells therapies will help India to further develop this sector. Until recently, there was a huge gap between India’s complementary stem cells research and therapy guidelines; which are currently identified to be barriers for their potential therapeutic applications.

Thus, in general India is more focused on fulfilling patients need with latest technological development; due to the growing socioeconomic burden of chronic diseases such as diabetes, heart problems, etc. While stem cells therapies have potential to meet the growing demands; India’s most of the common population is still unaware of the technology.

Stem Cells Treatments for Stroke

Many studies have reported that with the modern technology, it is now possible to treat massive diseases such as stroke with the help of patient’s own stem cells with more feasibility and safety. It has as well been reported that all the patients, who were involved in clinical studies very well tolerated the procedure with no complications, all the patients showed variable improvements, which was confirmed with the help of MRI and CT scan and lastly throughout the study, no signs of tumours or blood vessel malformation detected.

Similar proof of concept trials has concluded complete safety and feasibility of stem cells treatment; as a possible alternative option in demand for many deadly conditions such as stroke. Till date, conditions such as stroke or paralysis were treated to be ultimate conditions; people have to stay with rest of their lives. But with the advent of stem cells technology, the scenario took a swift u turn towards a new path of hope and wellness. Many ongoing clinical studies, such as the one listed above, have confirmed the rationale to motivate many scientists, who are actually working on the development of stem cells, based therapies.

Stem cells are the youngest cells observed in human development and are responsible for giving rise to all the trillions of cells in human body. These cells have the tremendous power of self-multiplication and regeneration without losing its ability over the period of time.  All these exclusive properties collectively signify them as very special candidates that can solve major health issues; which are troubling mankind currently.

Stroke is a condition displaying obstruction in the flow of blood towards the brain due to either blood clot or blood vessel damage. Brain cells are in constant demand of oxygen to survive and work more efficiently. Without a supply of oxygenated blood, there may be a huge neuronal cells death, halting the passage of information from brain to leading organs of the body. This may lead to unwanted consequences such as paralysis; making people be completely dependent for the rest of their lives.

With the help of stem cells based therapies, it is technically possible to infuse enriched stem cells either from autologous as well as allogeneic donor, to initiate new blood vessel formation, reduce the inflammation and regenerate the damaged cells to restore back the brain function to significant levels.

Thus, stem cells treatment for stroke can be a viable option to activate or energize weakened or dead neurons to gain control over lost functions after stroke attack.

Stem cells Treatments for Autism

The critical demand for effective treatment for children suffering from autism is increased in near future. In this regard, stem cells treatment for autism is much more of the easy choice, than it was often thought to be. One of the greatest breakthroughs that these stem cells might impose is a constant reminder of body’s innate ability to heal itself in the crisis.

Autism is not as such a deadly disorder, on the contrary in developing countries like India; very few people are aware of the fact that there children are suffering from this autistic. It is actually an umbrella term for wide variety of diseases ranging from mild to severe forms. Scientists have linked up the occurrence of the condition to various risk factors such as genetic abnormality, vaccine reaction, injury, exposure to heavy metals and pesticides during pregnancy and environmental allergies, etc. There are other unknown causes as well, which are yet to be confirmed.

More often, it has been observed that autistic child has difficulty in maintaining cognitive functions such as control, coordination, social interaction, concentration, etc. In this regard, hardcore research and clinical studies have increased the basic understanding of underlying mechanism. In autistic children, a connection between the brain and its abilities to perform cognitive functions has been observed to be halted due to neural degeneration or weakened neurons. Stem cells, due to their strong regeneration properties are reported to be integrating well with the microenvironment of the brain. These stem cells being anti-inflammatory in nature can prevent the initial inflammation of faulty immune system; secrete various growth factors, which can relevantly direct these stem cells to become resident tissue specific cells such as neurons in case of brain. These superior functions of stem cells are important for their potential applications in stem cells therapeutics for autism.

It has well to be noted that there cannot be guaranteed improvement for adult stem cells treatment to autism, however enough positive changes have been noted in children after getting infusion in stem cells treatment.

Explorations in the field of Stem Cell Treatment for Diabetes

Diabetes is one of the most dangerous diseases, as it stealthily attacks the body. People normally overlook the initial symptoms, but with time both type-1 and type-2 diabetes turns into a serious problem and can prove fatal for the patient. The degenerative consequences of this disease are primarily because of hypoglycemic events and hyperglycemia, which set off degenerative conditions. When it comes to treating degenerative diseases, stem cell treatment for diabetes is the option that seems the most suitable.

Researchers have come up with innovative autologous stem cell treatment to treat both kinds of diabetes. This kind of therapy deals with the root conditions like hyperglycemia as well as complications associated with it. Some recent trials have also shown that stem cell treatment for diabetes can also aid in curing Hypoglycemia, which can be very hazardous if suitable treatment is not administered in time. Researchers in India are also involved in clinical trials to develop safer stem cell treatment for diabetes in India.

Recently, researchers are examining Mesenchymal stem cells, which comes with differentiation as well as self-renewing capacity. This capability of differentiating into different cell types including vascular, cartilage, brain, bone, and other cells proves that these can also help in controlling diabetes mellitus. Further studies are being conducted to explore the potential of MSCs in treating diabetic neuropathy, cardiomyopathy, diabetic retinopathy, polyneuropathy, as well as wounds caused by diabetes.

Of late, many clinics have surfaced that provide stem cell treatment for diabetes in India. The main aim of giving a boost to stem cell treatment for diabetes in India is to provide prolonged life to Indian masses, to help in reducing the symptoms of both kinds of diabetes, along with preventing the risky complications like kidney failure, heart disease, and even blindness.

Earlier stem cell treatment was mainly prevalent in western or European countries, but now stem cell treatment even for type-1 diabetes is now available in India. Researchers in India are now trying to explore two major techniques to use stem cell for curing type-1 diabetes. The first one involves exploring the capacity of beta cells and the second involve cells supporting repair of beta cells in patients. 

Stem cells Treatments for Diabetes

In the developed countries, sedentary life styles, diet and other wrong adaptive habits can exact the toll of diabetes in millions of people; may be young as well as old. Over the period of time, research has unfolded many pages, which lead to better understanding of the mechanism but still the scarcity of effective treatment is troubling many medical practitioners. For decades now, researchers are making slow but steady development in the applications of stem cells treatment for diabetes.

Diabetes is basically categorized as the group of disorders that is deregulated by the body’s faulty immune system; leading to damaged insulin producing cells. This damage can alter the blood glucose metabolism, causing it to be accumulated in the blood. Due to long term exposure of this sweet blood to different functional organs, such as heart, kidney or vascular system; they can be damaged severely. Thus diabetes is a condition that can be asymptomatic in its initial phase but go bizarre in later part of its progression.

Conventionally, no treatment is available for the condition, except for some supportive treatment approach such as hormonal supplements, diet control, regular exercise and weight loss. People have to follow their schedule strictly to manage the symptoms for their rest of the lives. It has been estimated that each year more than 1500, whole pancreatic transplant take place with more than 85% success rate. However, the demand for organs outweighs their availability. Besides, to allow the body to accept the transplanted organ, the patient has to be on strong supplementation, which may risk his life by other opportunistic infections.

Scientists have worked hard on developing a potential stem cell treatment diabetes. Since own cells are destroyed in autoimmune diseases such as type 1 diabetes; more emphasize would be in regulating immunological cells to deny their access of destruction. Stem cells are the potent cells with the ability to differentiate into different cells types depending upon the requirement. Modern technology has allowed easy isolation of these cells from different organs such as bone marrow, adipose tissue, etc. and infused back at the specific sites after laboratory enrichment. These cells then reprogram immune cells, reduce the initial inflammation and regenerate weakened cells to restructure cellular system of the pancreas to make it functionally powerful.

Thus, after addressing various safety and feasibility issues in various clinical studies, it has been clear that stem cells are undoubtedly promising candidates for implementing stem cells based therapies as routine practices for diseases such as diabetes.

Stem Cell Therapy In India

In recent year stem cells and their power of regeneration has constantly been in news because of their potential and differentiation ability to develop. These potential applications are promising for treating variety of deadly, degenerative disorders, which cannot be cured completely with conventional treatment option. These applications of stem cells are still a debatable issue. People are more skeptical, still for their success and effectiveness. Sometimes, they are equipped with wrong information about this stem cells therapy. Probably they are still not able to differentiate between adult stem cells and embryonic stem cells.

Scientists have diverted their attention now to explore various different adult stem cells sources. This is the reason, why adult stem cells sources such as adipose tissues, dental pulp and bone marrow are being used very commonly without the hassles of ethical debate. These cells are supposed to be less controversial because of their easy availability and low risk associated with their isolation from host. Stem cells are the naïve, unique cells; which can differentiate into many new cells of different origin, depending upon their potency. No doubt adult stem cells are less potent as compared to embryonic stem cells but considering the other advantages in their applications; adult stem cells can definitely be scientist’s first choice for developing cell based therapies.

Right from the last decade, considerable advancement have been achieved in the field of regenerative medicine. Earlier scientists have to wait for not less than three weeks to reach to the conclusion, whereas now the scenario has changed completely due to the technology automation. Now days, results are out within an hour of the sample processing. Processing can as well be done directly at the point of care near the bedside of the patient, suffering from diseases. It has also been possible that these potential adult sources can be stored under controlled conditions to use whenever there is demand; as an individual’s healthcare security.

Stem cells therapy is found out to be very potent in diseases such as orthopaedics, neuromotor degeneration, cancers, autoimmune diseases, etc.

Thus, anecdotal evidences have proved that stem cells therapies considerable improvements can be noted in case of fatal conditions; for which conventionally no treatments can be offered.

Stem cells Treatments for ALS

The reported neurology journal have recently published a new exciting study on safety and efficacy of stem cells based therapy for devastating diseases such as ALS. The clinical studies have confirmed that stem cells have considerably slow down the progression of neuronal damage in ALS.

ALS or amyotrophic lateral sclerosis is an incurable disease; involving slow and progressive degeneration of motor neurons. Brain is the central processing organ of human body. It controls and coordinates with all the other organs with the passage of information from it through spinal cord. In case of ALS, due to neuronal damage; brain will not be able to pass on the information to different muscular organs of the body. Stem cells are known to be very promising candidates for maintaining the numbers of lost neurons.

Ongoing clinical studies have concluded that stem cells and their effective neuromuscular regeneration have slowed down the degradation to a considerable level. Scientists are trying to figure out different route of administration of cells. It has been observed that stem cells injected directly into the cerebrospinal fluid of the central nervous system are more effective than other routes. Once inside the body, these cells can easily reach to the site of injury due to the strong signalling and networking properties of these cells. Their anti-inflammatory characteristics can reduce the inflammation, secrete growth factors and can regulate immune cells to promote faster regeneration of tissue specific cells.

Currently, no conventional treatment is available for ALS. The only treatment that is been offered to ALS patients is physiotherapy, diet and positive attitude. However, along with these supplements stem cells infusion can be effective in slowing down the progression of the disease

Thus, scientists are more optimistic that in near future, a definitive treatment can be offered to ALS patients to slow down or stop the progression of the disease. It is believed that currently stem cells cannot be considered as a cure by any means but it can definitely be considered as the first step towards the cure.

Stem Cell Treatments for Cerebral Palsy

Cerebral palsy: an umbrella term for group of degenerative brain disorders, causing various degrees of neuromotor impairment and physical disability. Many factors can be openly link up with the condition such as but limited to infection before birth, premature birth, lack of oxygen as well as severe mental injury during birth. There is at present no treatment available conventionally that is been approved; but can stem cells treatment help and if the answer is yes, is it really necessary to wait for the approval?

Studies are ongoing to minimize the symptoms associated with the condition if not managed altogether. Various supportive treatments have been formulated such as physiotherapy, occupational therapy, etc. to improve locomotion and audiovisual skills of the children. Some oral muscular relaxants are available to tackle muscular stiffness and thereby functional loss. However, it has to be noted that all these treatments are only supplementary without any reversal in the condition. In this regard, various new strategies are being explored by the healthcare market to initiate an alternative solution that can make a big difference.

Stem cells treatment are expected to reverse the damage in the brain to reverse the symptoms. The disease is mainly associated with the neuronal damage, halting the transmission of signal from brain to different muscular organs of the body; leading to their damage. Scientists believe that the ability of stem cells is very impressive to change the scenario. Stem cells are known to be key cells in creating different tissue specific cells; during the human development. These cells with each division give rise to stem cells and tissue specific cells. The produced stem cells are stored by the organ’s future applications. These stored stem cells help the organ to cope up after normal wear and tear of the body. The advanced technology has now enabled to redirect different stem cells from different organs of the body and enrich them at the required site of injury to accelerate the recovery.

Thus, in case of neuronal diseases such as cerebral palsy, wherein the individual is affected with the high degree of brain cells death, stem cells treatment can definitely be useful in regenerating the weak cells or creating new cells to restore back the function to a significant degree.

Stem cells Treatments for Macular Degeneration

Age related macular degeneration is a type of degenerative eye disorder with the rigorous impact on the mental and physical well being of the individual. Considering the rising population getting affected with the problem, it has been estimated that by the end of 2020, more than 10 million people will be affected globally, impacting a socioeconomic burden of the healthcare market. It is the most obvious cause of vision loss in the elderly people; forcing them to be completely dependent, if untreated for a longer period of time.

As the name suggest, AMD is a progressive declinatory disorder of the macula; a central part of the retina. This is the primary organ responsible for vision. It has been cited from different studies that patients who are suffering with the diseases, have undergone major loss of macular photoreceptor cells such as rods and cones and supportive epithelial cells. There are full proof evidences that people who have undergone stem cells treatment with autologous as well as allogenic implantation of cells in the macular region; have restored their vision without any major side effects. Reports have also been published, which are concluding overall three lines improvement in the standard visual acuity charts with the notable improvement in general as well as peripheral vision.

Stem cells are the unique cells with the ability to differentiate into various cells, as per the signal initiation of the organ. These cells are present in abundance in many organs, which have been explored by through scientific advancements. These unique functions of stem cells symbolize them as very effective candidates to alter the pattern of treatment in a healthcare industry. They can definitely be opted as safe, effective solutions; available naturally in human body, which can alter the loss as swiftly as possible without much hassle of immune rejection, costly surgery or long term wait for organs.

The data has also listed, the safety and efficacy of the human stem cells to alter or stop the progressive visual loss in the people with the age related macular degeneration and have certainly marked an exciting step in applying stem cells as a safe options for effective medical conditions. 

Stem cells Treatment for Arthritis

Lifestyle changes have welcomed various health concerns like overweight, reduced bone density, infertility, etc.; which are indeed responsible for variety of underlying dangerous conditions such as arthritis. It has been estimated that around 50% people, over the age 65 can have arthritis. Hence, in developed countries, arthritis can be one of the leading health issues, which need to be tackled well within time to avoid increased social economic burden.

Arthritis can be categorized as an inflammatory, joint disorder; affecting multiple joints at a time. The condition has more than 100 subdivisions, with osteoarthritis and rheumatoid arthritis as the most common forms. It is simply known to be a slowly progressive disease, affecting persons of any age groups; although women are known to be more prevalent than men.

Our joints are made up of joining of two bones to allow easy movement. These joints are being protected with the underlying tissue named, cartilages. The cartilages are soft, spongy tissues; acting as beds in between the two bones. Due to the presences of these tissues, the friction between the two bones is reduced, while joints are in mobile state. The cartilages are as well supported with the presence of synovial fluid, which is helpful in shock absorption. Thus, the entire assembly can access an easy and long term functionality of joints. However, variety of issues such as obesity, smoking, poor diet, etc. can create non significant inflammatory responses, which can degenerate these supportive tissues such as cartilages and synovial fluid; exposing bones to outer shocks and friction, leading to their damage.

Stem cells are the young, privileged cells with the capacity to differentiate into cells of different origin. The property of stem cells can be uniquely identified to be potential treatment for arthritis patients. Autologous stem cells isolated from two different sources such as adipose tissue and/or bone marrow can provide mesenchymal and hematopoietic stem cells in abundance. These stem cells are enriched in the laboratory and infused back in the patient’s joints to avail maximum benefits of tissue function restoration. Once inside the body, these stem cells are known to reach at the site of injury, due to their strong communication pathways with other cells, secrete growth factors to reduce the inflammation and elicit strong immunological reactions to speed up the process of healing. Stem cells, in case of joints problems or arthritis are known to induce cells of Chondrocytes origin and get differentiated into cartilages. Once differentiated into cartilages, there can be reduced friction and pain associated with OA.

Thus, considering their anti-inflammatory and regenerative capacities; there are pretty good reasons to say that these stem cells can be good candidates for treatment.

To know more about Arthritis Treatment & Stem Cell therapy in India visit our website : giostar.com

Osteoarthritis Treatment in India

Osteoarthritis is  the most common form of arthritis, usual form of chronic disorder  related to the joints that is found in millions of people all across the globe. It is also know as degenerative  joint disease or degenerative arthritis that takes place due to the break down joint cartilage and the underlying bone. OA can affect any joint, but it occurs most often in knees, hips, lower back and neck, small joints of the fingers and the bases of the thumb and big toe.

Due to the breakdown of the cartilage, pain , selling up and discomfort in the movement of the joint is noticed and it can be seen in all age group and genders, however older people are highly prone to osteoartheritis. Considerable growth in osteoartheritis treatment in India is evident now a days. Initially Osteoartheritis was considered just a wear and tear in joint, which now getting more significant approach to treat the disease. Osteoarthritis is the main cause of joint pain both in animals and humans.  Natural cartilage regeneration is very limited and no current drug therapies are curative, but rather look to reduce the symptoms associated with the degeneration. More recently, the use of embryonic stem cell therapy for the treatment of arthritis, especially osteoarthritis.

The symptoms of osteoarthritis vary quite diversely, however few of the common traits of the disease include

Limited range of motion or stiffness 

Clicking or cracking sound when a joint bends

Mild swelling around a joint

Many people believe that the effects of osteoarthritis are inevitable, so they don’t do anything to manage it, however osteoarthritis treatment in India through stem cell therapy is gaining awareness and successful upward trend in the curing the disease.

Joint aspiration, MRI and X ray are the modes through which one can test if he/she is suffering from or a victim of Osteoarthritics Traditonally , getting involved in physical activity, streching and weight management was considered to tackle the disease, but development in the stem cell therapy and successful result of effective and efficient implementation of the treatment has proven the potential of the mode of treatment.

Osteoarthritis Treatment in India

Osteoarthritis is  the most common form of artheritis, usual form of chronic disorder  related to the joints that is found in millions of people all across the globe. It is also know as degenerative  joint disease or degenerative artheritis that takes place due to the brek down joint cartilage and the underlying bone. OA can affect any joint, but it occurs most often in knees, hips, lower back and neck, small joints of the fingers and the bases of the thumb and big toe.

Due to the breakdown of the cartilage, pain , selling up and discomfort in the movemnt of the joint is noticed and it can be seen in all age group and genders, however older people are highly prone to osteoartheritis. Considerable growth in osteoartheritis treatment in India is evident now a days. Initially Osteoartheritis was considered just a wear and tear in joint, which now getting more significant approach to treat the disease. Osteoarthritis is the main cause of joint pain both in animals and humans.  Natural cartilage regeneration is very limited and no current drug therapies are curative, but rather look to reduce the symptoms associated with the degeneration. More recently, the use of embryonic stem cell therapy for the treatment of artheritis, especially osteoartheritis.

The symptoms of osteoartheritis vary quite diversely, however few of the common traits of the disease include

Limited range of motion or stiffness 

Clicking or cracking sound when a joint bends

Mild swelling around a joint

Many people believe that the effects of osteoarthritis are inevitable, so they don’t do anything to manage it, however osteoartheritis treatment in India through stem cell therapy is gaining awareness and successful upward trend in the curing the disease.

Joint aspiration, MRI and X ray are the modes through which one can test if he/she is suffering from or a victim of Osteoartheritics.Traditonally , getting involved in physical activity, streching and weight management was considered to tackle the disease, but development in the stem cell therapy and successful result of effective and efficient implementation of the treatment has proven the potential of the mode of treatment.

Recent Progress In The Field Of Stem Cell Therapy

Research based on Stem Cell therapy is addressing a huge continuum of medical conditions using varied types of stem cells. Stem cells are an unlimited source of live cells, which comes with self-repair capability. Recently there has been a great progress in the field of research and development of Stem Cell therapy.  This has given hope for treatment of diverse degenerative diseases and disorders. The recognition of atypical population of these cells in organs and tissues has cropped up as a source of progenitor or multipotent stem cells, which can be used for tissue engineering and therapies based on replacement.

A few years back, limited funding and supply were the major roadblocks in the way of Stem Cell therapy in India. With the introduction of pluripotent cells, new possibilities have been generated for cancer investigations. Adult and embryonic cells put forward the possibility of transplanting cells for self-renewal. Treatment of burns has been a major achievement in Stem Cell therapy in India. The gene and Stem Cell therapy has been combined together for treating skin burns and blistering diseases. Other than skin related conditions, this therapy has also proved successful for curing immunodeficiency disorders. To treat such conditions, blood cells are extracted and are then introduced to a kind of adenosine deaminase gene in lab conditions before transplanting it back into the patient.

Existing research on Stem Cell therapy in India also focus on treatment of spinal cord injury. After the recognition of adult as well as embryonic neural cells and their localization, new avenues for treating spinal cord injury have come up. The target of such transplants includes neurodegenerative diseases, brain injury, and even stroke. In Europe, a trail on embryonic stem cell has been recently approved for treating a major reason behind blindness in adolescents.

The ultimate purpose of Stem Cell therapy is replacement of damaged organs, but with constant trial and research, the scope of this therapy is rising continuously. Trials to ensure efficiency and safety of such therapies are also in progress, so that these can made available on a wide scale across the globe, specifically in developing countries like India.

THE BETTER AND THE NEW WAY FOR ARTHRITIS TREATMENT

You will not find any single treatment option for varied rheumatic ailments, although you might come across drugs and therapies, which can control the condition. Normally the flow of traditional Arthritis Treatment starts with diagnosis of the kind of arthritis, followed by administration of drugs to control pain or inflammation, then physical therapies like physiotherapy and hydrotherapy are administered, and if these are not able to bring relief to the patient, then surgery is the last option.

There are however, a number of side effects of the current techniques. For instance, injury to the articular cartilage is a very significant apprehension in orthopedic surgical procedures. Thanks to our scientists and researchers, now mesenchymal Stem Cell therapy has been developed to tackle with the complications as well as side effects associated with the present Arthritis Treatment option, especially surgery.

Researchers are constantly studying the nature of stem cells to develop Stem Cell therapy that not just control the complications but can cure the root cause of such ailments. Mesenchymal stem cells feature both multi-potentiality and proliferative ability such as potential for differentiation.

Animal studies that have conducted of late has demonstrated positive outcome when mesenchymal stem cells were injected into the area affected with cartilage deficiency. Although a number of studies are being carried out around the world to develop Stem Cell therapy for Arthritis Treatment, but it still requires several clinical trials for assessing the usefulness of Stem Cell therapy using mesenchymal stem cells.

Many experts believe that injections of stem cells can impede the degenerative process and can even regenerate the injured cartilage. Earlier, majority of the studies conducted on Stem Cell therapy for Arthritis Treatment focused on repairing the primary area of cartilage damage, but in the last few years, researchers are also studying the possibility to cure the entire joint.

This can be done either by growing sufficient cartilage, which can rematerialize the whole joint or by utilizing stem cells that can put off the degeneration process. The safety of these therapies are still to be confirmed, but the constant efforts that people are putting in this field will soon provide safe as well as effective stem cell based Arthritis Treatment option.